— Product
ALLVIL 2ML INJ
PHENIRAMINE MELEATE 22.75MG 2ML INJ
ALLVIL 2ML INJ is an injection of pheniramine maleate 22.75 mg in 2 ml, a first-generation antihistamine given intramuscularly or by slow intravenous injection. It is used for acute allergic reactions — urticaria, angioedema, drug and insect-sting reactions, and allergic rhinitis where an oral dose is impractical — and as an adjunct in anaphylaxis after adrenaline has been given.
01
Benefits
- The injectable route gives rapid onset where an allergic reaction is severe or the patient cannot take oral medication.
- Blocks histamine H1 receptors, relieving the itching, weals and flushing of acute allergic reactions.
- Useful adjunct in anaphylaxis alongside adrenaline and corticosteroid, though never as a substitute for adrenaline.
- Widely used as pre-medication before transfusion or before agents with a known risk of hypersensitivity reaction.
- The sedating effect can be useful where itching is severe and disturbing sleep.
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Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Marked drowsiness and sedation
- Dry mouth, nose and throat
- Dizziness or unsteadiness
- Pain or stinging at the injection site
Less common
- Blurred vision
- Difficulty passing urine
- Fall in blood pressure, particularly after rapid intravenous injection
- Palpitations, or paradoxical restlessness and excitation
Stop and get medical help if any of these occur
- Severe drowsiness progressing to unresponsiveness
- Marked fall in blood pressure or fainting
- Seizures
- Difficulty breathing, or worsening of the reaction being treated
- Inability to pass urine
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Precautions
- For administration by a qualified healthcare professional only. Intravenous doses must be given slowly and with the patient monitored.
- Causes marked sedation. The patient must not drive or operate machinery for the rest of the day.
- Contraindicated in narrow-angle glaucoma, urinary retention, significant prostatic enlargement and pyloroduodenal obstruction.
- Contraindicated in neonates and premature infants, and not to be given with, or within fourteen days of, a monoamine oxidase inhibitor.
- Sedation is additive with alcohol, opioids, benzodiazepines and other central depressants — avoid the combination or reduce doses.
- Use with care in the elderly, in epilepsy, in asthma and in hepatic impairment.
- In anaphylaxis this is an adjunct only; adrenaline remains the first-line treatment.
- Use in pregnancy and breastfeeding only where clearly indicated.