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AZIM-LB TAB
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AZIM-LB TAB

AZITHROMYCIN 500MG + LACTIC ACID BACILLUS

AZIM-LB TAB combines azithromycin 500 mg with lactic acid bacillus, a probiotic included to offset the disturbance the antibiotic causes to the gut flora. It is used for the same respiratory, skin and soft-tissue infections as azithromycin alone, and suits patients who have previously had troublesome antibiotic-associated diarrhoea.

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01

Benefits

  • Azithromycin covers both common respiratory pathogens and the atypical organisms that beta-lactams do not reach.
  • Lactic acid bacillus helps re-establish the normal gut flora that broad-spectrum antibiotics deplete.
  • Reduces the incidence and severity of antibiotic-associated diarrhoea, a common reason patients abandon a course early.
  • Once-daily dosing over a short course, with the tissue-persistence advantage of azithromycin.
  • Particularly useful in patients with a history of gastrointestinal upset on antibiotics, and in the elderly.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Nausea or abdominal cramping
  • Bloating or flatulence
  • Diarrhoea or loose stools
  • Headache
Less common
  • Altered sense of taste
  • Raised liver enzymes on testing
  • Skin rash or itching
  • Constipation
Stop and get medical help if any of these occur
  • Severe, watery or bloody diarrhoea, during or in the weeks after the course
  • Yellowing of the skin or eyes, or dark urine
  • Palpitations, fainting, or an irregular heartbeat
  • Swelling of the face, lips or tongue, or difficulty breathing
  • Widespread rash with blistering or peeling skin
03

Precautions

  • Contraindicated in known hypersensitivity to azithromycin, erythromycin or any macrolide.
  • Azithromycin prolongs the QT interval. Avoid in congenital long QT syndrome, significant bradycardia or uncorrected electrolyte disturbance, and use with care with other QT-prolonging drugs.
  • The probiotic component should be avoided in severely immunocompromised patients, in central venous catheter carriers, and in the critically ill, where live organisms have rarely caused systemic infection.
  • Use with caution in significant hepatic impairment.
  • Complete the full prescribed course even once symptoms settle.
  • Separate dosing from aluminium- or magnesium-containing antacids by at least two hours.
  • Use in pregnancy and breastfeeding only where clearly indicated.