— Product
B-CPM INJ 30ML
CHLORPHENIRAMINE MALEATE INJ
B-CPM INJ 30ML is an injectable preparation of chlorpheniramine maleate, a first-generation antihistamine given intramuscularly, subcutaneously or by slow intravenous injection. It is used for acute allergic reactions — urticaria, angioedema, drug and transfusion reactions, insect stings — and as an adjunct in anaphylaxis after adrenaline has been administered.
01
Benefits
- Rapid onset by the injectable route, where an allergic reaction is severe or the oral route is unavailable.
- Blocks histamine H1 receptors, settling the itching, weals, flushing and swelling of acute allergic reactions.
- Well established as an adjunct in anaphylaxis alongside adrenaline and corticosteroid, though never as a replacement for adrenaline.
- Widely used as pre-medication before blood transfusion and before agents carrying a known hypersensitivity risk.
- The multi-dose presentation is convenient for clinic, emergency and day-care settings.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Sedation and drowsiness
- Dry mouth, nose and throat
- Dizziness or unsteadiness
- Stinging or pain at the injection site
Less common
- Blurred vision
- Difficulty passing urine
- Transient fall in blood pressure after intravenous injection
- Paradoxical excitation, restlessness or irritability, particularly in children and the elderly
Stop and get medical help if any of these occur
- Severe drowsiness progressing to unresponsiveness
- Marked fall in blood pressure or fainting
- Seizures
- Difficulty breathing, or worsening of the reaction being treated
- Inability to pass urine
03
Precautions
- For administration by a qualified healthcare professional only. Intravenous doses must be given slowly, with the patient monitored.
- Causes marked sedation. The patient must not drive or operate machinery for the rest of the day.
- Contraindicated in narrow-angle glaucoma, urinary retention, significant prostatic enlargement, and pyloroduodenal obstruction.
- Contraindicated in neonates and premature infants, and not to be given with or within fourteen days of a monoamine oxidase inhibitor.
- Sedation is additive with alcohol, opioids, benzodiazepines and other central depressants.
- Use with care in the elderly, in epilepsy, in asthma and in hepatic impairment.
- In anaphylaxis this is an adjunct only; adrenaline remains the first-line treatment.
- Use in pregnancy and breastfeeding only where clearly indicated.