— Product
BESTOMOX CV 625 LB TAB
AMOXY 500 + CLAUV POTAS 125MG + LACTOBACILLUS
BESTOMOX CV 625 LB TAB combines amoxicillin 500 mg and clavulanate potassium 125 mg with lactobacillus, a probiotic included to offset the gut disturbance the antibiotic causes. It covers the same infections as amoxicillin-clavulanate alone and suits patients who have previously had troublesome antibiotic-associated diarrhoea.
01
Benefits
- Clavulanate protects amoxicillin from beta-lactamase, extending cover to resistant organisms.
- Lactobacillus helps re-establish the gut flora that broad-spectrum antibiotics deplete.
- Reduces the incidence and severity of antibiotic-associated diarrhoea, which is the commonest reason this combination is abandoned mid-course.
- Particularly useful in the elderly and in patients with a history of gastrointestinal upset on antibiotics.
- Covers the mixed flora of dental, bite-wound and skin infection alongside common respiratory pathogens.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Diarrhoea or loose stools
- Nausea or vomiting
- Bloating or flatulence
- Abdominal discomfort
Less common
- Oral or vaginal thrush after the course
- Raised liver enzymes on testing
- Skin rash
- Constipation
Stop and get medical help if any of these occur
- Swelling of the face, lips or tongue, difficulty breathing, or collapse
- Yellowing of the skin or eyes, dark urine, or pale stools
- Severe, watery or bloody diarrhoea during or in the weeks after the course
- Widespread rash with blistering or peeling skin
- Unusual bruising or bleeding
03
Precautions
- Contraindicated in known penicillin allergy, and in any previous amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
- The probiotic component should be avoided in severely immunocompromised patients, in central venous catheter carriers, and in the critically ill.
- Clavulanate carries a risk of cholestatic jaundice, more so in the elderly and with prolonged courses.
- Take with food to improve clavulanate absorption and reduce diarrhoea.
- Dose reduction is required in significant renal impairment.
- Avoid in suspected infectious mononucleosis.
- Complete the full prescribed course even once symptoms settle.
- Use with caution where there is a cephalosporin allergy.