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BESTOMOX CV 625 LB TAB M/C
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BESTOMOX CV 625 LB TAB M/C

AMOXY 500MG + CLAUV POTASIUM 125MG + LACTIC ACID BACILLUS

BESTOMOX CV 625 LB TAB M/C combines amoxicillin 500 mg and clavulanate potassium 125 mg with lactic acid bacillus. The clavulanate protects the amoxicillin from bacterial beta-lactamase, and the probiotic offsets the gut disturbance the antibiotic causes. It is used for sinusitis, otitis media, respiratory, urinary, skin, dental and bite-wound infections.

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01

Benefits

  • Clavulanate inhibits beta-lactamase, restoring amoxicillin's activity against organisms that would otherwise destroy it.
  • Lactic acid bacillus helps re-establish the gut flora that broad-spectrum antibiotics deplete.
  • Reduces the antibiotic-associated diarrhoea that is the commonest reason this combination is stopped mid-course.
  • Covers beta-lactamase-producing Haemophilus, Moraxella and Staphylococcus aureus alongside the usual amoxicillin spectrum.
  • Twice-daily dosing is convenient and well established for the 625 mg strength.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Diarrhoea or loose stools
  • Nausea or vomiting
  • Bloating or flatulence
  • Abdominal discomfort
Less common
  • Oral or vaginal thrush after the course
  • Raised liver enzymes on testing
  • Skin rash
  • Constipation
Stop and get medical help if any of these occur
  • Swelling of the face, lips or tongue, difficulty breathing, or collapse
  • Yellowing of the skin or eyes, dark urine, or pale stools
  • Severe, watery or bloody diarrhoea during or in the weeks after the course
  • Widespread rash with blistering or peeling skin
  • Unusual bruising or bleeding
03

Precautions

  • Contraindicated in known penicillin allergy, and in any previous amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
  • The probiotic should be avoided in severely immunocompromised patients, central venous catheter carriers and the critically ill.
  • Clavulanate carries a risk of cholestatic jaundice, more so in the elderly, in men, and with courses beyond two weeks.
  • Take with food to improve clavulanate absorption and reduce diarrhoea.
  • Dose reduction is required in significant renal impairment.
  • Avoid in suspected infectious mononucleosis, where a florid rash is common.
  • Complete the full prescribed course, and use with caution where there is a cephalosporin allergy.