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CAREFIX-100 TAB
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CAREFIX-100 TAB

CEFIXIME 100MG

CAREFIX-100 TAB is a dry syrup of cefixime 100 mg, a third-generation oral cephalosporin, reconstituted before use. It is used in older children and where a higher dose is required, for otitis media, pharyngitis, sinusitis, bronchitis, typhoid fever and urinary tract infection caused by susceptible organisms.

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01

Benefits

  • Good activity against Gram-negative organisms including beta-lactamase-producing Haemophilus and Moraxella.
  • The 100 mg strength suits older or heavier children without needing large volumes of the lower strength.
  • Once- or twice-daily dosing improves the likelihood of completing the course.
  • An established oral option in uncomplicated typhoid fever, where it avoids the need for injectable therapy.
  • Absorption is not significantly affected by food.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Diarrhoea or loose stools
  • Nausea or vomiting
  • Abdominal discomfort
  • Skin rash
Less common
  • Oral or vaginal thrush after the course
  • Raised liver enzymes on testing
  • Headache or dizziness
  • Flatulence
Stop and get medical help if any of these occur
  • Swelling of the face, lips or tongue, difficulty breathing, or collapse
  • Severe, watery or bloody diarrhoea during or in the weeks after the course
  • Widespread rash with blistering or peeling skin
  • Yellowing of the skin or eyes
  • Persistent vomiting, or signs of dehydration
03

Precautions

  • Contraindicated in known cephalosporin allergy; use with caution where there is a penicillin allergy, and avoid entirely after penicillin anaphylaxis.
  • Reconstitute exactly to the mark, shake well before every dose, and use the measure supplied.
  • Store as directed after reconstitution and discard after the stated period.
  • Dose by body weight in children, on the prescriber's instruction.
  • Dose reduction is required in significant renal impairment.
  • Complete the full prescribed course even once symptoms settle.
  • Diarrhoea is common with cefixime; maintain fluid intake and report severe or bloody diarrhoea.