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CARIMOX CV 375 TAB
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CARIMOX CV 375 TAB

AMOXY 250MG + CLAUV POTASIUM 125MG

CARIMOX CV 375 TAB is a tablet combining amoxicillin 250 mg with clavulanate potassium 125 mg. The clavulanate protects the amoxicillin from bacterial beta-lactamase, and this lower 375 mg strength is used for milder infections or three-times-daily regimens in respiratory, urinary, skin, soft-tissue and dental infection.

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01

Benefits

  • Clavulanate inhibits beta-lactamase, restoring amoxicillin's activity against organisms that would otherwise destroy it.
  • Covers beta-lactamase-producing Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus.
  • The lower strength suits milder infections and smaller adults, and keeps the clavulanate load down.
  • A lower clavulanate dose per tablet means less of the diarrhoea that limits this combination.
  • Good cover for the mixed flora of dental infection and bite wounds.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Diarrhoea or loose stools
  • Nausea or vomiting
  • Abdominal discomfort
  • Skin rash
Less common
  • Oral or vaginal thrush after the course
  • Raised liver enzymes on testing
  • Headache or dizziness
  • Indigestion
Stop and get medical help if any of these occur
  • Swelling of the face, lips or tongue, difficulty breathing, or collapse
  • Yellowing of the skin or eyes, dark urine, or pale stools
  • Severe, watery or bloody diarrhoea during or in the weeks after the course
  • Widespread rash with blistering or peeling skin
  • Unusual bruising or bleeding
03

Precautions

  • Contraindicated in known penicillin allergy, and in any previous amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
  • Clavulanate carries a risk of cholestatic jaundice, more so in the elderly, in men, and with courses beyond two weeks.
  • Take with food, which improves clavulanate absorption and substantially reduces diarrhoea.
  • Dose reduction is required in significant renal impairment.
  • Avoid in suspected infectious mononucleosis, where a florid rash is common.
  • Complete the full prescribed course, and never use a leftover course for a new infection.
  • Use with caution where there is a cephalosporin allergy.