— Product
CEFTROS S 1.5GM INJ
CEFTRIAXONE 1GM + SULBACTAM 0.5GM
CEFTROS S 1.5GM INJ is an injection of ceftriaxone 1 g with sulbactam 0.5 g, a third-generation cephalosporin combined with a beta-lactamase inhibitor. It is used in hospital for serious infections caused by beta-lactamase-producing organisms — respiratory, urinary, intra-abdominal, skin and soft-tissue infection, and septicaemia.
01
Benefits
- Sulbactam inhibits beta-lactamase, extending ceftriaxone's cover to resistant organisms that would otherwise inactivate it.
- Sulbactam has intrinsic activity against Acinetobacter baumannii, an increasingly important hospital pathogen.
- Retains ceftriaxone's broad Gram-negative cover and good tissue penetration.
- Once- or twice-daily dosing simplifies administration in serious infection.
- A useful escalation where plain ceftriaxone has failed or resistant organisms are likely.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Pain or induration at the injection site
- Diarrhoea or loose stools
- Nausea
- Skin rash
Less common
- Raised liver enzymes on testing
- Eosinophilia or low white cell count
- Biliary sludging with right-upper-abdominal discomfort
- Thrombophlebitis at the infusion site
Stop and get medical help if any of these occur
- Swelling of the face, lips or tongue, difficulty breathing, or collapse
- Severe, watery or bloody diarrhoea during or in the weeks after the course
- Widespread rash with blistering or peeling skin
- Yellowing of the skin or eyes, or severe right-upper-abdominal pain
- Reduced urine output or blood in the urine
03
Precautions
- Contraindicated in neonates receiving or expected to receive calcium-containing intravenous fluids, and in hyperbilirubinaemic or premature neonates.
- Do not mix or co-administer through the same line with calcium-containing solutions including Ringer's lactate, at any age.
- Contraindicated in known cephalosporin allergy; use with caution in penicillin allergy and avoid after penicillin anaphylaxis.
- Do not mix in the same syringe or line as an aminoglycoside.
- Reserve for infections where a beta-lactamase inhibitor is genuinely needed, and de-escalate on culture results to limit resistance.
- Biliary sludging can occur with high doses and prolonged courses.
- Monitor blood counts and liver function during prolonged therapy.
- For administration by a qualified healthcare professional only.