— Product
DURA-AQUA 1ML
DICLOFENAC 75MG
DURA-AQUA 1ML is an aqueous injection of diclofenac 75 mg in 1 ml, given by deep intramuscular injection. It is used for acute severe pain — renal and biliary colic, acute musculoskeletal injury, post-operative pain, and acute exacerbations of arthritis — where rapid, potent analgesia is needed.
01
Benefits
- Rapid onset by injection, which matters most in renal colic where pain is severe and immediate.
- Diclofenac is highly effective in renal colic, where NSAIDs both relieve pain and reduce ureteric smooth muscle activity.
- The aqueous formulation is generally less painful at the injection site than older propylene glycol-based preparations.
- Useful post-operatively as part of a multimodal regimen, reducing opioid requirement.
- The small 1 ml volume is convenient for intramuscular administration.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Pain or induration at the injection site
- Nausea or epigastric discomfort
- Dizziness or headache
- Drowsiness
Less common
- Gastric erosion or bleeding
- Rise in blood pressure or fluid retention
- Raised liver enzymes
- Skin rash or itching
Stop and get medical help if any of these occur
- Black, tarry stools or vomiting of blood
- Chest pain, breathlessness, or weakness or numbness down one side
- Swelling of the face, lips or tongue, or difficulty breathing
- A marked fall in urine output
- Severe pain, redness or swelling at the injection site
03
Precautions
- For administration by a qualified healthcare professional, by deep intramuscular injection into the upper outer quadrant of the buttock only.
- Diclofenac carries a higher cardiovascular risk than several other NSAIDs. Contraindicated in established ischaemic heart disease, cerebrovascular disease, peripheral arterial disease and moderate to severe heart failure.
- Contraindicated in active peptic ulcer disease or a history of gastrointestinal bleeding.
- Contraindicated in severe hepatic or renal impairment, and in NSAID hypersensitivity including aspirin-sensitive asthma.
- Contraindicated in the third trimester of pregnancy.
- Limit to the shortest course possible — typically no more than two days of injection before switching to an oral route.
- Ensure adequate hydration, as NSAID-related renal injury is far more likely in a volume-depleted patient.
- Do not give alongside another NSAID, and use with caution with anticoagulants, corticosteroids, diuretics and ACE inhibitors.