— Product
GENTAROS INJ 2ML
GENTA 2ML INJ
GENTAROS INJ 2ML is a 2 ml injection of gentamicin, an aminoglycoside antibiotic given intramuscularly or by intravenous infusion. It is used for serious Gram-negative infections — septicaemia, complicated urinary tract, intra-abdominal, respiratory and skin infections — often alongside a beta-lactam antibiotic.
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Benefits
- Bactericidal against a broad range of Gram-negative organisms including Escherichia coli, Klebsiella, Proteus and Pseudomonas.
- Acts synergistically with beta-lactam antibiotics, a combination long established in serious sepsis and in endocarditis.
- Concentration-dependent killing with a post-antibiotic effect, supporting once-daily regimens that are effective and less nephrotoxic.
- Achieves high urinary concentrations, useful in complicated urinary tract infection.
- Long-established, widely available and inexpensive.
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Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Pain or redness at the injection site
- Nausea or vomiting
- Headache
- Rash
Less common
- Rise in serum creatinine indicating renal impairment
- Ringing in the ears or a sense of fullness in the ear
- Dizziness or unsteadiness from vestibular effects
- Low serum magnesium, potassium or calcium
Stop and get medical help if any of these occur
- Any new hearing loss, ringing in the ears, or vertigo — these may become permanent
- A marked fall in urine output
- Muscle weakness or difficulty breathing
- Numbness or tingling of the face or extremities
- Severe rash, facial swelling or difficulty breathing
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Precautions
- Gentamicin is nephrotoxic and ototoxic. Renal function must be checked before and during treatment, and hearing assessed where courses are prolonged.
- Dose must be adjusted to renal function and body weight, with therapeutic drug monitoring — particularly in the elderly, in renal impairment, and beyond a few days of treatment.
- Contraindicated in known aminoglycoside hypersensitivity and in pre-existing significant hearing or vestibular impairment.
- Contraindicated in pregnancy — aminoglycosides cross the placenta and can cause irreversible congenital deafness.
- Avoid concurrent loop diuretics, amphotericin B, vancomycin and other nephrotoxic or ototoxic agents where possible.
- Contraindicated or used with extreme caution in myasthenia gravis, as it can precipitate neuromuscular blockade.
- Keep the patient well hydrated and limit courses to the shortest clinically effective duration.
- For administration by a qualified healthcare professional. Do not mix in the same syringe or line as a beta-lactam antibiotic.