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GENTAROS INJ 30ML
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GENTAROS INJ 30ML

GENTA 30ML INJ

GENTAROS INJ 30ML is a 30 ml multi-dose vial of gentamicin injection, an aminoglycoside antibiotic given intramuscularly or by intravenous infusion. It is used for serious Gram-negative infections, in a presentation suited to repeated hospital and clinic use.

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01

Benefits

  • Bactericidal against a broad range of Gram-negative organisms including Escherichia coli, Klebsiella, Proteus and Pseudomonas.
  • Acts synergistically with beta-lactam antibiotics in serious sepsis and endocarditis.
  • Concentration-dependent killing with a post-antibiotic effect, supporting once-daily dosing.
  • Achieves high urinary concentrations, useful in complicated urinary tract infection.
  • The multi-dose vial suits wards and clinics where the drug is used frequently.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Pain or redness at the injection site
  • Nausea or vomiting
  • Headache
  • Rash
Less common
  • Rise in serum creatinine indicating renal impairment
  • Ringing in the ears or a sense of fullness in the ear
  • Dizziness or unsteadiness from vestibular effects
  • Low serum magnesium, potassium or calcium
Stop and get medical help if any of these occur
  • Any new hearing loss, ringing in the ears, or vertigo — these may become permanent
  • A marked fall in urine output
  • Muscle weakness or difficulty breathing
  • Numbness or tingling of the face or extremities
  • Severe rash, facial swelling or difficulty breathing
03

Precautions

  • Nephrotoxic and ototoxic. Check renal function before and during treatment, and assess hearing where courses are prolonged.
  • Multi-dose vial: use strict aseptic technique at every withdrawal, record the date of first puncture, and discard after the stated in-use period.
  • Dose must be adjusted to renal function and body weight, with therapeutic drug monitoring.
  • Contraindicated in aminoglycoside hypersensitivity, in pre-existing hearing or vestibular impairment, and in pregnancy.
  • Avoid concurrent loop diuretics, amphotericin B, vancomycin and other nephrotoxic or ototoxic agents where possible.
  • Contraindicated or used with extreme caution in myasthenia gravis.
  • Keep the patient well hydrated and limit courses to the shortest effective duration.
  • Do not mix in the same syringe or line as a beta-lactam antibiotic.