— Product
GLYCYROSS M1 SR TAB
Glimepiride IP 1mg- Metformin Hcl IP 500mg
GLYCYROSS M1 SR TAB is a tablet combining glimepiride 1 mg with sustained-release metformin 500 mg, for type 2 diabetes mellitus. It is used where metformin alone no longer achieves adequate glycaemic control, adding a sulphonylurea to stimulate insulin secretion.
01
Benefits
- Combines two complementary mechanisms — metformin reduces hepatic glucose production and insulin resistance, glimepiride stimulates insulin release from the pancreas.
- The sustained-release metformin causes markedly less gastrointestinal upset than the immediate-release form.
- A single tablet replaces two, which improves adherence in a lifelong condition.
- Glimepiride 1 mg is the lowest starting strength, appropriate for cautious initiation.
- Once-daily dosing with the sustained-release formulation.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Hypoglycaemia — sweating, tremor, hunger, palpitations, confusion
- Nausea or abdominal discomfort
- Diarrhoea
- Weight gain from the glimepiride
Less common
- Metallic taste
- Dizziness or headache
- Skin rash
- Vitamin B12 deficiency with long-term metformin use
Stop and get medical help if any of these occur
- Severe hypoglycaemia with confusion, seizures or loss of consciousness
- Deep rapid breathing, severe weakness, muscle pain and vomiting — this may be lactic acidosis
- Yellowing of the skin or eyes
- Widespread rash with blistering or peeling skin
- Unusual bruising or bleeding
03
Precautions
- Glimepiride causes hypoglycaemia, which can be severe and prolonged, particularly in the elderly, in renal impairment, with missed meals, and with alcohol. Every patient must know the symptoms and carry fast-acting glucose.
- Never skip meals while taking this. Missing a meal after a dose is the commonest cause of hypoglycaemia.
- Metformin can cause lactic acidosis — stop during acute illness with dehydration, before iodinated contrast procedures, and before major surgery.
- Contraindicated in type 1 diabetes, diabetic ketoacidosis, significant renal impairment and severe hepatic impairment.
- Swallow the sustained-release tablet whole; crushing or chewing releases the full metformin dose at once.
- Take with the first main meal of the day, and avoid excess alcohol.
- Beta-blockers mask the warning signs of hypoglycaemia — warn patients taking both.
- Contraindicated in pregnancy and breastfeeding; check vitamin B12 periodically on long-term use.