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GLYCYROSS-M2 SR TAB
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GLYCYROSS-M2 SR TAB

GLIMEPIRIDE 2MG + METFORMIN 500MG SR

GLYCYROSS-M2 SR TAB is a tablet combining glimepiride 2 mg with sustained-release metformin 500 mg, for type 2 diabetes mellitus. It is used where a lower glimepiride strength has proved insufficient, at double the sulphonylurea dose with the same metformin component.

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01

Benefits

  • Combines two complementary mechanisms — metformin reduces hepatic glucose production and insulin resistance, glimepiride stimulates insulin release.
  • The 2 mg glimepiride strength suits patients inadequately controlled on 1 mg.
  • Sustained-release metformin causes markedly less gastrointestinal upset than the immediate-release form.
  • A single tablet replaces two, improving adherence in a lifelong condition.
  • Once-daily dosing with the sustained-release formulation.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Hypoglycaemia — sweating, tremor, hunger, palpitations, confusion
  • Nausea or abdominal discomfort
  • Diarrhoea
  • Weight gain from the glimepiride
Less common
  • Metallic taste
  • Dizziness or headache
  • Skin rash
  • Vitamin B12 deficiency with long-term metformin use
Stop and get medical help if any of these occur
  • Severe hypoglycaemia with confusion, seizures or loss of consciousness
  • Deep rapid breathing, severe weakness, muscle pain and vomiting — this may be lactic acidosis
  • Yellowing of the skin or eyes
  • Widespread rash with blistering or peeling skin
  • Unusual bruising or bleeding
03

Precautions

  • Hypoglycaemia risk is higher at this glimepiride strength. Every patient must know the symptoms and carry fast-acting glucose.
  • Never skip meals while taking this.
  • Metformin can cause lactic acidosis — stop during acute illness with dehydration, before iodinated contrast procedures, and before major surgery.
  • Contraindicated in type 1 diabetes, diabetic ketoacidosis, significant renal impairment and severe hepatic impairment.
  • Swallow the sustained-release tablet whole; do not crush or chew.
  • Take with the first main meal of the day, and avoid excess alcohol.
  • Beta-blockers mask the warning signs of hypoglycaemia.
  • Use with particular caution in the elderly, where prolonged hypoglycaemia is a real hazard. Contraindicated in pregnancy and breastfeeding.