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INDOXIME-200 CV TAB M/C
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INDOXIME-200 CV TAB M/C

CEFIXIME 200MG + CLAUV ACID 125MG

INDOXIME-200 CV TAB M/C is a tablet combining cefixime 200 mg with clavulanic acid 125 mg. The clavulanate protects the cefixime from bacterial beta-lactamase, extending its cover to resistant organisms in respiratory, urinary, skin and soft-tissue infections.

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01

Benefits

  • Clavulanate inhibits beta-lactamase, restoring cefixime's activity against organisms that would otherwise inactivate it.
  • Broadens cover to include beta-lactamase-producing strains not reliably covered by cefixime alone.
  • A useful escalation where a plain cefixime course has failed or resistant organisms are likely.
  • Retains the convenience of twice-daily oral dosing.
  • Provides an oral option in infections that might otherwise need injectable therapy.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Diarrhoea, which is more frequent than with cefixime alone
  • Nausea or vomiting
  • Abdominal discomfort
  • Skin rash
Less common
  • Oral or vaginal thrush after the course
  • Raised liver enzymes on testing
  • Headache or dizziness
  • Indigestion
Stop and get medical help if any of these occur
  • Swelling of the face, lips or tongue, difficulty breathing, or collapse
  • Yellowing of the skin or eyes, dark urine, or pale stools
  • Severe, watery or bloody diarrhoea during or in the weeks after the course
  • Widespread rash with blistering or peeling skin
  • Reduced urine output
03

Precautions

  • Contraindicated in known cephalosporin allergy; use with caution in penicillin allergy and avoid after penicillin anaphylaxis.
  • Clavulanate carries a risk of cholestatic jaundice, more so in the elderly and with prolonged courses. Keep courses short.
  • Take with food, which reduces the diarrhoea and gastric upset.
  • Dose reduction is required in significant renal impairment.
  • Complete the full prescribed course, and reserve this combination for cases where a beta-lactamase inhibitor is genuinely needed rather than using it first-line.
  • Diarrhoea is common; maintain fluid intake and report severe or bloody diarrhoea.
  • Use in pregnancy and breastfeeding only where clearly indicated.