— Product
INDOXIME-O TAB M/C
CEFIXIME 200MG + OFLOXACIN 200MG
INDOXIME-O TAB M/C is a tablet combining cefixime 200 mg with ofloxacin 200 mg, pairing a third-generation cephalosporin with a fluoroquinolone. It is used for mixed or resistant infections — complicated urinary tract, respiratory, gastrointestinal and gynaecological infections — where broader cover than either agent alone is required.
01
Benefits
- Combines two different antibiotic classes, broadening cover across Gram-positive, Gram-negative and atypical organisms.
- Ofloxacin adds activity against organisms cefixime does not reliably cover, including Pseudomonas and staphylococci.
- Useful in complicated urinary tract infection and in typhoid fever where resistance is a concern.
- Both components are well absorbed orally, allowing treatment of relatively serious infection without injection.
- Twice-daily dosing keeps the regimen practical.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Nausea or vomiting
- Diarrhoea or loose stools
- Abdominal discomfort
- Headache or dizziness
Less common
- Insomnia or restlessness
- Increased sensitivity to sunlight
- Raised liver enzymes on testing
- Skin rash
Stop and get medical help if any of these occur
- Pain, swelling or rupture of a tendon, particularly the Achilles
- Numbness, tingling, burning or weakness in the hands or feet
- Severe, watery or bloody diarrhoea during or in the weeks after the course
- Seizures, confusion, hallucinations or severe anxiety
- Palpitations or fainting
- Swelling of the face, lips or tongue, or difficulty breathing
03
Precautions
- Fluoroquinolones can cause tendon damage and rupture, peripheral neuropathy and central nervous system effects, which may be irreversible. Stop at the first sign of tendon pain or new numbness and tingling.
- Tendon risk is much higher in the elderly, in patients on corticosteroids, and in transplant recipients.
- Contraindicated in children and adolescents, in pregnancy and in breastfeeding.
- Contraindicated in known hypersensitivity to cephalosporins or quinolones, in a history of tendon disorder with a quinolone, and in myasthenia gravis, which fluoroquinolones can worsen.
- Ofloxacin prolongs the QT interval — avoid in known QT prolongation, uncorrected electrolyte disturbance, and alongside other QT-prolonging drugs.
- Separate from antacids, calcium, iron and zinc by at least two hours, as these bind the fluoroquinolone and prevent absorption.
- Avoid excessive sun exposure, and maintain good fluid intake.
- A two-antibiotic combination should be reserved for cases where it is genuinely justified, not used first-line — indiscriminate use drives resistance.