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M CROSS 4 TAB AL/AL
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M CROSS 4 TAB AL/AL

METHYLPREDNSIOLONE 4MG

M CROSS 4 TAB AL/AL is a tablet of methylprednisolone 4 mg, a corticosteroid. It is used in inflammatory and autoimmune conditions — rheumatoid arthritis, asthma, allergic disorders, inflammatory bowel disease, skin conditions and connective tissue disease — where systemic corticosteroid therapy is indicated.

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01

Benefits

  • Potent anti-inflammatory and immunosuppressive action across a wide range of inflammatory and autoimmune conditions.
  • Minimal mineralocorticoid activity, so it causes less sodium and water retention than hydrocortisone or prednisolone.
  • The 4 mg strength allows flexible titration and controlled tapering, and suits the tapering dose packs commonly used for short courses.
  • Effective in asthma exacerbations, allergic reactions and inflammatory flares where a short oral course is needed.
  • Once-daily morning dosing matches the natural cortisol rhythm and reduces adrenal suppression.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Increased appetite and weight gain
  • Rise in blood glucose
  • Insomnia, restlessness or mood change
  • Indigestion
Less common
  • Rise in blood pressure and fluid retention
  • Acne, thinning skin or easy bruising
  • Muscle weakness, particularly of the thighs and shoulders
  • Menstrual irregularity
Stop and get medical help if any of these occur
  • Signs of infection — fever, sore throat, cough — as steroids mask and worsen infection
  • Severe abdominal pain, or black or tarry stools
  • Marked confusion, agitation or psychotic symptoms
  • Very high blood glucose with thirst, frequent urination and drowsiness
  • Sudden severe hip, shoulder or knee pain, which may indicate avascular necrosis
  • Blurred vision or eye pain
03

Precautions

  • Never stop abruptly after more than a short course. Prolonged use suppresses the adrenal axis, and sudden withdrawal can cause an adrenal crisis. Taper under supervision.
  • Corticosteroids mask the signs of infection and impair the response to it. Chickenpox and measles can be severe in a steroid-treated patient without immunity.
  • Live vaccines are contraindicated during and shortly after significant corticosteroid therapy.
  • Raises blood glucose. Diabetic patients need closer monitoring and often an increase in their usual therapy.
  • Prolonged use causes osteoporosis; bone protection should be considered for courses beyond three months.
  • Use with caution in peptic ulcer disease, uncontrolled hypertension, heart failure, glaucoma, epilepsy and psychiatric illness.
  • Take in the morning with food. Patients on long-term therapy should carry a steroid card.
  • Use in pregnancy and breastfeeding only where clearly indicated.