— Product
MECAROSE PLUS 2ML INJ SYRINGE
METHYLCOBALAMINE + PYRIDOXINE HYD + NICOTINAMIDE + BENZY ALCOHOL I.P
MECAROSE PLUS 2ML INJ SYRINGE is a 2 ml prefilled injection combining methylcobalamin, pyridoxine hydrochloride and nicotinamide, given intramuscularly. It is used in peripheral neuropathy, vitamin B12 deficiency with neurological features, and in B-vitamin deficiency where oral absorption is impaired.
01
Benefits
- The injectable route bypasses the gut entirely, essential in pernicious anaemia and in malabsorption where oral B12 is not absorbed.
- Methylcobalamin is the active coenzyme form of vitamin B12, directly involved in myelin formation and nerve repair.
- Pyridoxine and nicotinamide support nerve metabolism and energy production.
- Corrects deficiency faster than oral supplementation, which matters where neurological symptoms are present and time-sensitive.
- The prefilled syringe removes dose measurement errors and suits clinic use.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Pain or redness at the injection site
- Flushing or warmth of the skin from the nicotinamide
- Nausea
- Headache
Less common
- Itching or rash
- Dizziness
- Transient fall in blood pressure
- Metallic taste
Stop and get medical help if any of these occur
- Swelling of the face, lips or tongue, difficulty breathing, or collapse
- Widespread rash or hives
- Severe flushing with dizziness or fainting
- New numbness or tingling on prolonged high-dose pyridoxine
- Severe pain, swelling or redness at the injection site
03
Precautions
- For administration by a qualified healthcare professional, by intramuscular injection.
- Establish the cause of B12 deficiency before treating. Pernicious anaemia requires lifelong replacement, and treating without diagnosis leaves the cause unaddressed.
- Correcting B12 deficiency can unmask hypokalaemia as red cell production resumes — monitor in severe deficiency.
- Prolonged high-dose pyridoxine causes peripheral neuropathy; do not continue courses indefinitely without review.
- Nicotinamide flushing is common and harmless but alarming — warn the patient.
- Do not give folic acid alone to a patient with possible B12 deficiency, as it corrects the anaemia while neurological damage progresses.
- Contraindicated in known hypersensitivity to any component or to benzyl alcohol, which is present as a preservative.
- Contraindicated in neonates because of the benzyl alcohol content; use in pregnancy and breastfeeding only on medical advice.