MEFROS-TX TAB MC

• Tranexamic acid inhibits fibrinolysis in the endometrium, substantially reducing menstrual blood loss — often by a third to a half.
• Mefenamic acid reduces menstrual loss further and, unlike tranexamic acid, also relieves the cramping pain.
• Together they address the two symptoms — heavy bleeding and pain — that most often occur together in menorrhagia.
• Non-hormonal, so it suits women who cannot use or do not want hormonal treatment.
• Taken only during the days of bleeding rather than continuously through the cycle.

Not everyone gets these. Most are mild and settle as the course finishes.

• Tranexamic acid increases the risk of thrombosis. Contraindicated in active thromboembolic disease, in a history of deep vein thrombosis or pulmonary embolism, and in patients with a known thrombophilia.
• Use with caution alongside combined hormonal contraceptives, which independently raise thrombotic risk.
• Contraindicated in a history of seizures and in subarachnoid haemorrhage.
• Heavy menstrual bleeding needs a diagnosis. Fibroids, polyps, thyroid disease, bleeding disorders and endometrial pathology all require different management, and treating symptomatically can delay that.
• Contraindicated in active peptic ulcer disease, inflammatory bowel disease, severe hepatic or renal impairment, and NSAID hypersensitivity.
• Diarrhoea with mefenamic acid is a reason to stop the drug.
• Report any visual disturbance immediately and stop the medicine.
• Dose reduction is required in renal impairment; take with or after food and limit to the days of bleeding.