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MUPIRITE OINTMENT 5MG
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MUPIRITE OINTMENT 5MG

MUPIROCIN 2%

MUPIRITE OINTMENT 5MG is a topical ointment of mupirocin 2%, a bacterial protein synthesis inhibitor. It is used for impetigo, infected minor wounds, cuts, abrasions and folliculitis, and for eradicating nasal carriage of Staphylococcus aureus including MRSA.

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01

Benefits

  • Highly effective against Staphylococcus aureus and streptococci, the organisms responsible for most superficial skin infection.
  • Active against MRSA, which is why it is reserved for nasal decolonisation before surgery and in outbreak control.
  • First-line topical treatment for localised impetigo, avoiding the need for oral antibiotics.
  • A unique mechanism of action, so there is no cross-resistance with other antibiotic classes.
  • Minimal systemic absorption from intact skin, so it is well tolerated.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Burning or stinging on application
  • Itching at the application site
  • Local redness
  • Dryness of the treated skin
Less common
  • Contact dermatitis with persistent redness
  • Worsening of the rash rather than improvement
  • Sensitisation on repeated use
  • Nasal irritation when used intranasally
Stop and get medical help if any of these occur
  • Spreading redness, warmth, swelling, pus or fever
  • Severe blistering or ulceration of the treated skin
  • Swelling of the face, lips or tongue, or difficulty breathing
  • No improvement after three to five days of treatment
  • Red streaks spreading from the wound
03

Precautions

  • Mupirocin is a valuable reserve agent for MRSA. Restrict use to short defined courses of five to ten days — casual and prolonged use drives mupirocin resistance and will destroy its usefulness.
  • For external use only. Avoid the eyes; rinse thoroughly if contact occurs.
  • Do not use on large areas of broken skin or extensive wounds, where the polyethylene glycol base can be absorbed and is a concern in renal impairment.
  • Contraindicated in known hypersensitivity to mupirocin.
  • Cover the treated area with a dressing where appropriate, and avoid sharing towels or bedding — impetigo is highly contagious.
  • Not for burns, deep or heavily contaminated wounds, or infections needing systemic antibiotics.
  • Seek review if there is no improvement after three to five days.
  • Use in pregnancy and breastfeeding only on medical advice.