— Product
NEPROSEN-D 250 TAB(S T)
NAPROXEN 250MG + DOMPERIDONE 10MG
NEPROSEN-D 250 TAB(S T) is a tablet of naproxen 250 mg with domperidone 10 mg. It is used for pain and inflammation in arthritis, musculoskeletal disorders, period pain and migraine, with the domperidone included to counter the nausea that both the condition and the NSAID can cause.
01
Benefits
- Naproxen has a longer duration of action than most NSAIDs, allowing twice-daily rather than more frequent dosing.
- Naproxen carries a lower cardiovascular risk than diclofenac and the coxibs, which makes it a preferred NSAID in patients with cardiovascular risk factors.
- Effective in dysmenorrhoea, where it reduces both pain and menstrual blood loss.
- Domperidone relieves the nausea that accompanies migraine and that NSAIDs themselves can provoke.
- Domperidone also speeds gastric emptying, which improves absorption of the naproxen during a migraine attack.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Nausea, indigestion or epigastric discomfort
- Abdominal pain or diarrhoea
- Headache or dizziness
- Dry mouth
Less common
- Gastric erosion, ulceration or gastrointestinal bleeding
- Fluid retention or a rise in blood pressure
- Breast tenderness or milk secretion from raised prolactin
- Skin rash or itching
Stop and get medical help if any of these occur
- Palpitations, fainting or an irregular heartbeat
- Black, tarry stools or vomiting of blood
- Muscle stiffness, tremor, restlessness or involuntary movements
- Yellowing of the skin or eyes
- A marked fall in urine output
- Widespread rash with blistering or peeling skin
03
Precautions
- Domperidone prolongs the QT interval and has been associated with serious arrhythmia and sudden cardiac death. Use at the lowest effective dose for the shortest period — generally no more than a week — and avoid in cardiac disease or electrolyte disturbance.
- Contraindicated alongside other QT-prolonging drugs and strong CYP3A4 inhibitors including ketoconazole, erythromycin and clarithromycin.
- Contraindicated in active peptic ulcer disease, gastrointestinal haemorrhage, mechanical obstruction and prolactin-releasing pituitary tumour.
- Contraindicated in severe hepatic or renal impairment, and in NSAID hypersensitivity including aspirin-sensitive asthma.
- Avoid in the third trimester of pregnancy; use earlier in pregnancy and while breastfeeding only on medical advice.
- Take with or after food, and avoid alcohol during the course.
- Use with caution in the elderly, in cardiovascular disease, and alongside anticoagulants, corticosteroids or other NSAIDs.
- Use the lowest effective dose for the shortest period that controls symptoms.