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NETIDINE 2ML AMP
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NETIDINE 2ML AMP

RANITIDINE 25MG 2ML INJ

NETIDINE 2ML AMP is an injection of ranitidine 25 mg per ml in a 2 ml ampoule, an H2 receptor antagonist given intramuscularly or by slow intravenous injection. It is used where oral therapy is impractical — in acute upper gastrointestinal bleeding, stress ulcer prophylaxis, and as pre-operative aspiration prophylaxis.

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01

Benefits

  • The injectable route works where the patient is vomiting, nil by mouth, or unable to absorb oral medication.
  • Rapid reduction of gastric acid secretion, useful in acute settings.
  • Used pre-operatively to raise gastric pH and reduce the risk of acid aspiration during anaesthesia.
  • Used for stress ulcer prophylaxis in critically ill patients.
  • Convenient small-volume ampoule for ward and theatre use.
02

Side effects

Not everyone gets these. Most are mild and settle as the course finishes.

Common
  • Pain or stinging at the injection site
  • Headache
  • Dizziness
  • Nausea
Less common
  • Transient fall in blood pressure after rapid intravenous injection
  • Skin rash
  • Raised liver enzymes
  • Confusion in the elderly or in renal impairment
Stop and get medical help if any of these occur
  • Slow or irregular heartbeat, particularly after rapid intravenous injection
  • Confusion, agitation or hallucinations
  • Swelling of the face, lips or tongue, or difficulty breathing
  • Yellowing of the skin or eyes
  • Continued vomiting of blood or passage of black stools
03

Precautions

  • For administration by a qualified healthcare professional. Intravenous doses must be diluted and given slowly — rapid injection can cause bradycardia and hypotension.
  • Ranitidine has been withdrawn or restricted in several countries following NDMA detection; prescribers should be aware of the current regulatory position.
  • Dose reduction is required in significant renal impairment.
  • Acid suppression treats the acid, not the bleeding — active upper gastrointestinal haemorrhage needs endoscopic assessment and management.
  • Contraindicated in known hypersensitivity to ranitidine.
  • Use with caution in the elderly, where confusion is more likely.
  • Use in pregnancy and breastfeeding only where clearly indicated.