— Product
NETIDINE D TAB
RANITIDINE + DOMPERIDONE
NETIDINE D TAB is a tablet combining ranitidine with domperidone, pairing acid suppression with a prokinetic. It is used for gastro-oesophageal reflux, acid dyspepsia and reflux accompanied by nausea, bloating or a sensation of fullness.
01
Benefits
- Ranitidine reduces gastric acid secretion, relieving heartburn and acid symptoms.
- Domperidone increases gastric emptying and lower oesophageal sphincter tone, reducing the reflux itself.
- The prokinetic action relieves nausea, bloating and early fullness that acid suppression alone does not address.
- Particularly useful in reflux associated with delayed gastric emptying.
- Faster symptomatic onset than a proton pump inhibitor.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Headache
- Dry mouth
- Diarrhoea or constipation
- Abdominal discomfort
Less common
- Dizziness
- Breast tenderness or enlargement, and milk secretion, from raised prolactin
- Menstrual irregularity
- Skin rash
Stop and get medical help if any of these occur
- Palpitations, fainting or an irregular heartbeat
- Muscle stiffness, tremor, restlessness or involuntary movements
- Black or tarry stools, or vomiting of blood
- Difficulty swallowing, unexplained weight loss or persistent vomiting
- Confusion or hallucinations
03
Precautions
- Domperidone prolongs the QT interval and has been associated with serious arrhythmia and sudden cardiac death. Contraindicated in known QT prolongation, electrolyte disturbance and underlying cardiac disease; use at the lowest effective dose for no more than about a week.
- Contraindicated alongside other QT-prolonging drugs and strong CYP3A4 inhibitors including ketoconazole, erythromycin and clarithromycin.
- Contraindicated in gastrointestinal haemorrhage, mechanical obstruction or perforation, and in prolactin-releasing pituitary tumour.
- Ranitidine has been withdrawn or restricted in several countries following NDMA detection; be aware of the current regulatory position.
- Alarm features — weight loss, difficulty swallowing, vomiting blood, black stools, anaemia — need investigation before starting acid suppression.
- Dose reduction is required in renal impairment for both components.
- Take before meals for the prokinetic effect, and use in pregnancy and breastfeeding only on medical advice.