— Product
NIMOROSS TAB GREEN
NIMESULIDE 100MG
NIMOROSS TAB GREEN is a tablet of nimesulide 100 mg, an NSAID with preferential COX-2 activity. It is used for the short-term treatment of acute pain and inflammation — musculoskeletal injury, dental pain, dysmenorrhoea and post-operative pain — for a maximum of fifteen days.
01
Benefits
- Rapid onset of analgesia, often within fifteen to thirty minutes, which is faster than most oral NSAIDs.
- Preferential COX-2 activity gives anti-inflammatory effect with somewhat less gastric impact than non-selective NSAIDs.
- Effective in acute musculoskeletal injury, dental pain and dysmenorrhoea.
- Useful where a rapid effect matters, such as acute dental or post-traumatic pain.
- Also has antipyretic activity.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Nausea, indigestion or epigastric discomfort
- Diarrhoea
- Dizziness or headache
- Skin rash
Less common
- Gastric erosion or bleeding
- Raised liver enzymes on testing
- Fluid retention
- Itching or sweating
Stop and get medical help if any of these occur
- Yellowing of the skin or eyes, dark urine, pale stools, persistent nausea or loss of appetite — nimesulide can cause severe liver injury
- Black, tarry stools or vomiting of blood
- A marked fall in urine output
- Swelling of the face, lips or tongue, or difficulty breathing
- Widespread rash with blistering or peeling skin
03
Precautions
- Nimesulide carries a recognised risk of severe hepatotoxicity, including liver failure. It has been withdrawn in several countries and is restricted to second-line use for a maximum of fifteen days. Stop immediately at any sign of liver dysfunction.
- Contraindicated in children under twelve years.
- Contraindicated in any hepatic impairment or history of hepatic reaction to nimesulide, and in alcohol or drug dependence.
- Contraindicated in active peptic ulcer disease, gastrointestinal bleeding, severe renal impairment, and NSAID hypersensitivity including aspirin-sensitive asthma.
- Contraindicated in pregnancy and breastfeeding.
- Avoid alcohol entirely and avoid concurrent hepatotoxic drugs, including paracetamol at high dose.
- Use only where other NSAIDs are unsuitable, at the lowest effective dose and for the shortest possible period.
- Take with or after food, and counsel the patient on the symptoms of liver injury before starting.