— Product
OFLOROSS-OZ TAB B/L
OFLOXACIN 200MG + ORNIDAZOLE 500MG
OFLOROSS-OZ TAB B/L is a tablet combining ofloxacin 200 mg with ornidazole 500 mg, a fluoroquinolone paired with a nitroimidazole. It is used for infective diarrhoea and dysentery, mixed aerobic and anaerobic infections, and gynaecological and intra-abdominal infections.
01
Benefits
- Ofloxacin covers the common bacterial causes of infective diarrhoea and a broad range of Gram-negative organisms.
- Ornidazole covers Entamoeba histolytica, Giardia and anaerobic organisms that ofloxacin does not reach.
- Empirical cover across both groups is useful in mixed or undiagnosed infective diarrhoea.
- Ornidazole has a longer half-life than metronidazole and is generally better tolerated, with less metallic taste and nausea.
- Useful in pelvic inflammatory disease and intra-abdominal infection where aerobes and anaerobes coexist.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Nausea or vomiting
- Metallic taste
- Abdominal discomfort
- Headache or dizziness
Less common
- Dark urine
- Increased sensitivity to sunlight
- Insomnia or restlessness
- Skin rash
Stop and get medical help if any of these occur
- Pain, swelling or rupture of a tendon, particularly the Achilles
- Numbness, tingling, burning or weakness in the hands or feet
- Seizures, confusion, hallucinations or severe anxiety
- Severe, watery or bloody diarrhoea during or in the weeks after the course
- Palpitations or fainting
- Swelling of the face, lips or tongue, or difficulty breathing
03
Precautions
- Fluoroquinolones can cause tendon damage and rupture, peripheral neuropathy and central nervous system effects, which may be permanent. Stop at the first sign of tendon pain or new numbness.
- Tendon risk is much higher in the elderly, on corticosteroids, and in transplant recipients.
- Contraindicated in children and adolescents, in pregnancy and in breastfeeding.
- Contraindicated in known hypersensitivity to quinolones or nitroimidazoles, in a history of tendon disorder with a quinolone, and in myasthenia gravis.
- Ornidazole causes less of a disulfiram reaction than metronidazole, but alcohol is still best avoided during the course.
- Separate from antacids, calcium, iron and zinc by at least two hours.
- Rehydration is the priority in acute diarrhoea; antibiotics are an adjunct and are unnecessary in most cases.
- Avoid excessive sun exposure and use with caution alongside warfarin.