— Product
PANTARITE-DSR CAP AL/AL
PANTOPRAZOLE 40MG + DOMPERIDONE 30MG(SR)
PANTARITE-DSR CAP AL/AL is a capsule combining pantoprazole 40 mg with sustained-release domperidone 30 mg. It is used for gastro-oesophageal reflux, acid dyspepsia and reflux with nausea, bloating or fullness, with the sustained-release prokinetic allowing once-daily dosing.
01
Benefits
- Pantoprazole blocks the gastric proton pump, producing sustained acid suppression.
- Domperidone increases gastric emptying and lower oesophageal sphincter tone, reducing reflux itself.
- The sustained-release domperidone gives prokinetic cover across the day from a single capsule.
- Relieves the nausea, bloating and early fullness that acid suppression alone does not address.
- Pantoprazole has fewer drug interactions than omeprazole.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Headache
- Diarrhoea or constipation
- Abdominal pain or flatulence
- Dry mouth
Less common
- Nausea or dizziness
- Breast tenderness or enlargement, and milk secretion, from raised prolactin
- Menstrual irregularity
- Skin rash
Stop and get medical help if any of these occur
- Palpitations, fainting or an irregular heartbeat
- Muscle stiffness, tremor, restlessness or involuntary movements
- Severe or persistent diarrhoea
- Severe muscle cramps, weakness or confusion, which may indicate low magnesium
- Black or tarry stools, or vomiting of blood
03
Precautions
- The 30 mg sustained-release domperidone is a higher daily dose than the 10 mg immediate-release form. Domperidone's QT prolongation and arrhythmia risk is dose-related — use for the shortest period possible and avoid in cardiac disease.
- Contraindicated in known QT prolongation, significant electrolyte disturbance, and alongside other QT-prolonging drugs or strong CYP3A4 inhibitors.
- Contraindicated in gastrointestinal haemorrhage, mechanical obstruction or perforation, and in prolactin-releasing pituitary tumour.
- Take thirty to sixty minutes before food.
- Swallow the capsule whole; crushing or chewing destroys both the enteric coating and the sustained-release mechanism.
- Long-term proton pump inhibitor use is associated with low magnesium and vitamin B12, fracture risk and enteric infection.
- Alarm features need investigation before starting acid suppression.