— Product
RABENXT-D TAB 20'S
RABEPRAZOLE + DOMPERIDONE
RABENXT-D TAB 20'S is a tablet combining rabeprazole with domperidone, pairing a proton pump inhibitor with a prokinetic. It is used for gastro-oesophageal reflux, acid dyspepsia and reflux accompanied by nausea, bloating or a sensation of fullness.
01
Benefits
- Rabeprazole produces rapid and sustained acid suppression, with the fastest onset of the proton pump inhibitors.
- Domperidone increases gastric emptying and lower oesophageal sphincter tone, reducing reflux itself.
- The prokinetic action relieves nausea, bloating and early fullness that acid suppression alone does not address.
- Rabeprazole has fewer drug interactions than omeprazole.
- Particularly useful in reflux associated with delayed gastric emptying.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Headache
- Diarrhoea or constipation
- Abdominal pain or flatulence
- Dry mouth
Less common
- Nausea or dizziness
- Breast tenderness or enlargement, and milk secretion, from raised prolactin
- Menstrual irregularity
- Skin rash
Stop and get medical help if any of these occur
- Palpitations, fainting or an irregular heartbeat
- Muscle stiffness, tremor, restlessness or involuntary movements
- Severe or persistent diarrhoea
- Severe muscle cramps, weakness or confusion, which may indicate low magnesium
- Black or tarry stools, or vomiting of blood
03
Precautions
- Domperidone prolongs the QT interval and has been associated with serious arrhythmia and sudden cardiac death. Contraindicated in known QT prolongation, electrolyte disturbance and cardiac disease; use for no more than about a week.
- Contraindicated alongside other QT-prolonging drugs and strong CYP3A4 inhibitors including ketoconazole, erythromycin and clarithromycin.
- Contraindicated in gastrointestinal haemorrhage, mechanical obstruction or perforation, and in prolactin-releasing pituitary tumour.
- Take thirty to sixty minutes before food.
- Swallow whole; do not crush or chew the enteric-coated tablet.
- Long-term proton pump inhibitor use is associated with low magnesium and vitamin B12, fracture risk and enteric infection. Review the need periodically.
- Alarm features — weight loss, difficulty swallowing, vomiting blood, black stools, anaemia — need investigation before starting.