— Product
RABERITE-L CAP
RABEPRAZOLE 20MG + LEVOSULPRIDE 75MG
RABERITE-L CAP is a capsule combining rabeprazole 20 mg with levosulpiride 75 mg, a proton pump inhibitor paired with a prokinetic and antiemetic. It is used for gastro-oesophageal reflux and functional dyspepsia with prominent nausea, bloating and early fullness.
01
Benefits
- Rabeprazole produces rapid and sustained acid suppression, healing oesophagitis and relieving reflux.
- Levosulpiride is a dopamine D2 antagonist that accelerates gastric emptying and has a central antiemetic effect.
- Particularly useful in functional dyspepsia and diabetic gastroparesis, where delayed emptying drives the symptoms.
- The antiemetic action helps where nausea is a prominent complaint.
- One capsule replaces two separate medicines.
02
Side effects
Not everyone gets these. Most are mild and settle as the course finishes.
Common
- Drowsiness or sedation
- Headache
- Dry mouth
- Breast tenderness or enlargement, and milk secretion, from raised prolactin
Less common
- Menstrual irregularity or absence of periods
- Reduced libido
- Diarrhoea or constipation
- Weight gain
- Restlessness
Stop and get medical help if any of these occur
- Muscle stiffness, tremor, restlessness, or involuntary movements of the face and tongue
- Any persistent involuntary movement — tardive dyskinesia may be irreversible
- High fever with muscle rigidity, confusion and sweating
- Severe muscle cramps, weakness or confusion, which may indicate low magnesium
- Black or tarry stools, or vomiting of blood
03
Precautions
- Levosulpiride is a dopamine antagonist and can cause extrapyramidal effects — parkinsonism, acute dystonia and, with prolonged use, tardive dyskinesia, which may be permanent. Restrict to short courses and review regularly.
- Risk of extrapyramidal effects is much higher in the elderly and with prolonged use. Avoid long-term treatment.
- Contraindicated in Parkinson's disease, in phaeochromocytoma, in prolactin-dependent tumours and in epilepsy.
- Contraindicated in gastrointestinal haemorrhage, mechanical obstruction or perforation.
- Raised prolactin commonly causes breast symptoms, milk secretion and menstrual disturbance — warn the patient before starting.
- Causes drowsiness. Warn before driving, and avoid alcohol.
- Take thirty to sixty minutes before food, and swallow whole.
- Alarm features need investigation before starting acid suppression.